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Post Amputation Pain Treatment

Post-Amputation Pain and Phantom Limb Pain

What is Post Amputation Pain?

Limb loss is one of the most physically and psychologically devastating events that can happen to a person for a number or reasons, including disfigurement and loss of independence. The pain associated with loss of a limb can be categorized in one of three ways: phantom limb pain (PLP), residual limb pain or “stump pain” (RLP), and phantom sensations. The number of amputees who experience at least one of these three types of categories can be as high as 95%.

PLP is a painful or unpleasant sensation in the distribution of the missing body part. This type of pain is often described as a burning, sharp, shooting, aching, pressure, and electrical in nature. It may be perceived as affecting the whole limb or just one region of the missing limb. PLP usually occurs within 6 months of the loss of the limb and may be present at 2-3 years post amputation in as many as 85% of amputees. In addition, it can persist for years after surgical amputation.

There are approximately 185,000 new extremity amputations performed each year in the US. Of these, 86% involve lower extremities (feet, legs) and 14% involve upper extremities (hands, arms). With regards to amputations performed in lower extremities, below knee amputations are by far the most common making up 71% of the total. It is estimated that approximately 2 million Americans are currently living with some form of limb amputation.

RLP or “stump pain” is usually localized to the remaining body part after amputation. It is frequently described as sharp, dull, aching, burning, and shocking in nature. It can be perceived to involve just the distal end of the stump or throughout the entire residual limb. The pain can be located deep within the residual limb but it can also be superficial in nature, often involving the skin, making it very painful to touch or rub. This is a major reason for patients not being able to tolerate wearing a prosthetic limb. The incidence of stump pain is reported to be as high as 75%.

Phantom sensation are defined as non-painful perceptions in the distribution of the lost body part that may be perceived as movement of the missing body part, size, shape or position of the missing body part, or sensations such as touch, pressure, vibration, tingling, itch, or temperature. This phenomenon occurs in as many as 2/3 of major limb amputees.

Post-amputation Pain or (PAP) Treatment

Although there are all kinds of ways to categorize and describe post amputation pain (PAP), to the patient, it is often difficult to distinguish one category of pain from another. Traditionally, both phantom pain and stump pain have been very difficult to treat. When peripheral nerves are cut, they will invariably form neuromas as they try, and fail, to reconnect with the other end of the nerve which has been disposed of along with the amputated body part. These “stump” neuromas, along with potential compression neuropathies, can be responsible for both the pain in the residual limb, as well as at least some types of phantom pain. Phantom pain is theorized to involve processes which occur at the level of the brain and spinal cord in addition to peripheral mechanism which can make it more difficult to treat.

When a nerve is cut, there is sprouting of the nerve fibers (axons) on the “live” end of the nerve or the end which is still attached to the spinal cord. If the nerve is not repaired surgically, the live end of the nerve will usually form a painful structure known as a “neuroma.” A neuroma is simply a tangled mass of these sensitive nerve endings stuck in a ball of scar tissue. Each axon in our body is programmed into the brain to identify a specific area of the body. When something touches the bottom of your big toe, those nerve fibers transport a signal to the brain which lets the brain know that the big toe has been touched. In effect, those particular nerve fibers “represent” the bottom of your big toe in the brain. If you were to cut across those nerve fibers just below the level of the knee joint as part of a below knee amputation, it doesn’t change the way the brain identifies them. To the brain, the injured nerve fibers are still identified with the bottom of the big toe.

Postamputation Pain or (PAP) Causes

Now, supposing those fibers end up becoming stuck in a neuroma that is right down nerve the end of the amputation stump. Any time something pushes or stimulates the neuroma, the axons mapped to the bottom of the big toes can send a painful signal to the brain which may make you feel like the bottom of your big toe is being stabbed with a pin, shocked, or even burned with a hot coal. Neuromas can also produce painful sensations in the ends of the stumps or even pain which can radiate throughout the remaining part of the limb as well. If nerves which have been partially amputated also go to areas of skin, or of the prosthesis rubs or puts pressure on these nerves, this can result in a situation where the skin itself can become painful to even the lightest touch. This can make wearing a prosthesis nearly impossible.

The traditional approach to treating stump neuromas has been to make small incisions down at the end of the stump, try and find the neuroma amidst all the scar tissue (a losing proposition) and then just cut the nerve back a couple of centimeters and hope for the best. This approach is almost invariably doomed to failure because even if the surgeon can find the neuroma, or multiple neuromas as is often the case, it is only a matter of time before a new neuroma will grow back and the problem starts all over again.

There is now a much better approach to treating both the phantom and stump pain that arises due to peripheral nerve neuromas after amputation. With a detailed understanding of peripheral nerve anatomy, the surgeon can make incisions located remotely from the amputation stump. It is then possible to find the specific nerve responsible for the pain and disconnect them. Special techniques are then employed to prevent another painful neuroma from developing which includes burying the proximal ends of the nerve in muscle or attaching cadaveric nerve grafts which allow the native nerves to grow into them and then “burn out” before a painful neuroma can be formed. This also removes the end of the nerve away from the area where it can be irritated by the prosthesis or stretched by movement across the knee joints.

Where there was previously little hope for amputees, there are now good options to relieve both stump and potentially phantom pain. This can allow the amputee to resume wearing a prosthesis comfortably, restoring greater mobility and independence, as well as provide a major psychological boost.

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